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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 1 Documents
 1 
Search results for , issue " Vol 12 No 2, 2001" : 1 Documents clear
IDENTIFICATION OF PENTAGAMAVUNON-0 METABOLITE IN FAECES AFTER INTRAVENOUS INJECTION OF WHITE-MALE SPRAGUE DAWLEY-DERIVED RATS Hadi, Feriyanto Trisna; ., Sugiyanto; ., Oetari
INDONESIAN JOURNAL OF PHARMACY Vol 12 No 2, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.064 KB) | DOI: 10.14499/indonesianjpharm0iss0pp72-78

Abstract

The compound 2,5-bis-(4’-hydroxy-3’-methoxybenzilidin) cyclopentanone or Pentagamavunon-0 (PGV-0) as the new anti-inflamatory drug candidate, is one of curcumin structure modification. Identification of metabolites in faeces could be strengthen the whole information about biotransformation of drug and could be use for studying on PGV-0 metabolites which are excreted through bile. Male Sprague Dawley derived rats were used in all experiments. PGV-0 was given intravenously using dose at 40 mg/kg BB. Then the faeces callected after 24 and 48 hours. The metabolite investigation devided into two parts, etil acetate fraction and water fraction, of faeces. The faeces which is excreted after 24 hours, found was more-polar metabolite according to PGV-0; it has shoft-yellow flourencese and having Rf value = 0,48 on TLC, using silica gel F254 as the stationary phase and etil acetate as the mobile phase. No PGV-0 glucuronide and sulfate metabolites were detectable in faeces, which are excreted on 24 or 48 hours.Key words : Pentagamavunon-0, biotransformation, intravenous, faeces

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